CARCINOGENICITY OF SOME ANTICANCER DRUGS—A SURVEY
نویسندگان
چکیده
منابع مشابه
Carcinogenicity of the anticancer topoisomerase inhibitor, amsacrine, in Wistar rats.
Amsacrine is an antineoplastic drug used in the treatment of acute adult leukemias. To assess its carcinogenic potential, groups of 50 male and 50 female rats were administered amsacrine by lateral tail vein injection at 0 (vehicle control), 0.25, 1, or 3 mg/kg once daily for 5 days, followed by a 23-day recovery period. This cycle of dosing and recovery was repeated a total of six times. The a...
متن کاملAnticancer activity of some bisbenzimidazoles.
The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. Bisbenzimidazole derivatives are important compounds known as DNA topoisomerase I inhibitors. In the present study, some symmetrical bisbenzimidazole derivatives were synthesized and investigated for their anticancer activity. Anticancer activity screening was applied on HT-29 (colon carcinoma) and M...
متن کاملsome properties of fuzzy hilbert spaces and norm of operators
in this thesis, at first we investigate the bounded inverse theorem on fuzzy normed linear spaces and study the set of all compact operators on these spaces. then we introduce the notions of fuzzy boundedness and investigate a new norm operators and the relationship between continuity and boundedness. and, we show that the space of all fuzzy bounded operators is complete. finally, we define...
15 صفحه اولPrevention of Carcinogenicity of Anticancer Drugs by Metal loth i»nei n Induction1
We examined the efficacy of metallothionein induction in the prevention of the carcinogenic action of ci'.v-platiimin and melphalan administered repeatedly to mice over a relatively long period. The increased pulmonary metallothionein induced by bismuth or zinc compounds during the period of chemotherapy with (-/¿-platinumor melphalan protected the mice from carcinogenesis of these drugs in th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Pharmacy and Therapeutics
سال: 1985
ISSN: 0269-4727,1365-2710
DOI: 10.1111/j.1365-2710.1985.tb00921.x